Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine
An Le, Kai J Huang, Lauren R Cirrincione
Transgender medicine is a diverse and growing clinicalfield with unmet gaps in
pharmacological knowledge. Hormone therapy (testosterone or estrogen treat-
ment), one part of the standard of medical care for transgender adults, aligns
secondary sex characteristics with an individual’s gender identity and expres-
sion. Despite established effects of sex steroids on drug-metabolizing enzyme
expression and activityin vitroand in animal models, the effect of long-term,
supraphysiological sex hormone treatment on drug metabolism in transgender
adults is not yet established. Here, we synthesize availablein vitroand animal
model data with pharmacological concepts in transgender medicine to predict
potential effects of sex steroids on drug-metabolizing enzymes, and their rela-
tionship with potential hormone–drug interactions, in transgender medicine.
pharmacological knowledge. Hormone therapy (testosterone or estrogen treat-
ment), one part of the standard of medical care for transgender adults, aligns
secondary sex characteristics with an individual’s gender identity and expres-
sion. Despite established effects of sex steroids on drug-metabolizing enzyme
expression and activityin vitroand in animal models, the effect of long-term,
supraphysiological sex hormone treatment on drug metabolism in transgender
adults is not yet established. Here, we synthesize availablein vitroand animal
model data with pharmacological concepts in transgender medicine to predict
potential effects of sex steroids on drug-metabolizing enzymes, and their rela-
tionship with potential hormone–drug interactions, in transgender medicine.
หมวดหมู่:
ปี:
2022
ภาษา:
english
จำนวนหน้า:
11
ไฟล์:
PDF, 1.65 MB
IPFS:
,
english, 2022
Amazon 
Barnes & Noble 
Bookshop.org 
สามารถแปลงไฟล์ได้
ผลการค้นหาเพิ่มเติม
สิทธิประโยชน์อื่นๆ 
คำที่ถูกค้นหาบ่อยที่สุด
บุ๊กลิสต์ที่เกี่ยวข้อง
